Department of Biological Functions and Engineering,

Graduate School of Life Science and Systems Engineering,

Kyushu Institute of Technology

Hibikino 2-4, Wakamatsu-ku, Kitakyushu, Fukuoka 808-0196, JAPAN

Biography

Prof. Masaaki Tamagawa was born on 28^th July, 1965. He obtained his Master degree in 1990 from The University of Tokyo (Institute of Industrial Science), and later he received his Doctor of Engineering in 1996 from Kyoto University, Japan. During his Doctoral study, he became Research Associate at Department of Mechanical Engineering, Faculty of Engineering, Kyoto University. Shortly after graduated he began his career as lecturer at Kyoto University. In 2003, he moved to Kyushu Institute of Technology to become Associate Professor. In 2010, he became full professor at the same university. He was also a guest researcher at Institute of Fluid Mechanics, University of Erlangen, Germany during 1996 – 1997.

His current main research interests are Biofluid Engineering and Medical Engineering, focusing on several projects including Development of Drug Delivery Systems with shock waves, Prediction method of Hemolysis and Thrombus formation in blood flow for medical fluidics. He has published research findings in cited journals and conferences, and active in societies such as JSME (Japan Society of Mechanical Engineer), JSMBE (Japanese Society for Medical and Biological Engineering). He has secured many grant aids from the Japanese government, as has won Young Investigator Award (The Seguchi Prize) from Bioengineering Division, JSME (Japan Society of Mechanical Engineer ) in 2000.

Abstract 

           Title : Design of special microcapsules including gas bubbles for drug delivery systems by shock waves

In this presentation, design and development of shock wave drug delivery systems, especially deformation process of a bubble in a microcapsule composed of membrane, liquid and gas bubble, are talked. Although there are so many drug delivery capsule and systems, their main targets are to make functional capsule membrane and control by changing membrane structure. It is preferable for the therapies to control actively by external method such as ultrasonic and shock wave because it is easy to apply these devices in the hospital.

For this reason, we have proposed drug delivery systems (DDS) using shock waves. This method is efficient way to transfer drugs near the affected part in human body, because there are no thermal effects on the living tissue by using shock wave comparing with that by the ultrasonic. The mechanical properties of membrane and geometry of the membrane is important parameter for changing the penetration strength of micro-jet in the microcapsule. The relations between the elasticity of capsule membrane and the probability of disintegration of membrane by shock-induced micro-jet from a bubble were clarified. But the effects of structures of the capsule composed of membrane, liquid and gas on disintegration rate of capsule have not been elucidated yet.

To find the optical design of microcapsule using gas ratio and membrane thickness, it is necessary to observe the deformation process of a bubble inside a capsule. For actual applications, it is also necessary to make microcapsules made of liposome composed of membrane, liquid and gas. In this presentation, (1) making polymer microcapsules including a bubble and analysis of a bubble deformation process in a polymer capsule by pressure wave, (2) making liposome microcapsules with different elastic membrane and disintegration tests by ultrasonic, are talked.